Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31218441 | 0.83 | KDM4E (0.41) | KDM4EMAOAMAOBBACE1ALDH1A1 | |
| SCHEMBL20582309 | 0.83 | KDM4E (0.41) | KDM4EMAOAMAOBBACE1ALDH1A1 | |
| SCHEMBL22028370 | 0.81 | LMNA (0.37) | KDM4EBACE1ALDH1A1NSD2MAPT | |
| SCHEMBL31218461 | 0.81 | LMNA (0.37) | KDM4EBACE1ALDH1A1NSD2MAPT | |
| SCHEMBL7059007 | 0.77 | KDM4E (0.58) | KDM4ECYP3A4CYP2C19HIF1ABACE1 | |
| SCHEMBL22028368 | 0.75 | MAOA (0.38) | KDM4EMAOAMAOBBACE1CHRM1 | |
| SCHEMBL31218446 | 0.75 | MAOA (0.38) | KDM4EMAOAMAOBBACE1CHRM1 | |
| SCHEMBL22028265 | 0.74 | TLR8 (0.44) | BACE1HTTMAT2A | |
| Hydrochloric Acid SCHEMBL28383603 | 0.74 | TLR8 (0.43) | HTTMAT2A | |
| SCHEMBL29303290 | 0.72 | KDM4E (0.42) | KDM4EMAOAMAOBBACE1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111065626-B | Compounds for the treatment of huntington's disease | PTC医疗公司 | 2024-09-27 | — | — | CN | disclosed |
| CN-111065626-A | Compounds for the treatment of huntington's chorea | PTC医疗公司 | 2020-04-24 | — | — | CN | disclosed |