Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224980 | 0.91 | HPGD (0.56) | RPS6KB2HPGDALDH1A1LMNAHTT | |
| SCHEMBL11210790 | 0.88 | HPGD (0.64) | RPS6KB2HPGDALDH1A1LMNAMAPT | |
| SCHEMBL11209038 | 0.88 | HPGD (0.64) | RPS6KB2HPGDALDH1A1LMNAMAPT | |
| SCHEMBL11247358 | 0.88 | HPGD (0.64) | RPS6KB2HPGDALDH1A1LMNAMAPT | |
| SCHEMBL11204556 | 0.88 | HPGD (0.64) | RPS6KB2HPGDALDH1A1LMNAMAPT | |
| SCHEMBL11235323 | 0.88 | HPGD (0.64) | RPS6KB2HPGDALDH1A1LMNAMAPT | |
| SCHEMBL31066042 | 0.84 | CYP4F2 (0.46) | HPGDALDH1A1LMNAHSD17B10MAPT | |
| SCHEMBL1432890 | 0.83 | ACACA (0.41) | HPGDALDH1A1HTTHSD17B10MAPT | |
| SCHEMBL9794742 | 0.80 | RPS6KB2 (0.43) | RPS6KB2HPGDALDH1A1LMNAHTT | |
| SCHEMBL13402922 | 0.78 | KDM1A (0.39) | HPGDALDH1A1LMNAHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107176944-B | Thiophene carboxylic acid compound or derivative thereof, pharmaceutical composition, preparation method and application thereof | 中国科学院上海药物研究所 | 2020-05-01 | — | — | CN | disclosed |