Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.40 |
| ▸ | PDE6C | P51160 | 2/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28388897 | 1.00 | PDE5A (0.40) | PDE5APDE6CPDE11APOLBLMNA | |
| SCHEMBL28391902 | 1.00 | PDE5A (0.40) | PDE5APDE6CPDE11APOLBLMNA | |
| SCHEMBL28388905 | 0.84 | MTNR1A (0.44) | PDE5APDE6CPDE11A | |
| SCHEMBL28388904 | 0.84 | MTNR1A (0.44) | PDE5APDE6CPDE11A | |
| SCHEMBL28391908 | 0.84 | MTNR1A (0.44) | PDE5APDE6CPDE11A | |
| SCHEMBL838180 | 0.65 | KMT2A (0.75) | POLBLMNAPKMKMT2AL3MBTL1 | |
| SCHEMBL13687172 | 0.63 | GAA (0.59) | POLBLMNAKMT2AL3MBTL1MEN1 | |
| SCHEMBL1943035 | 0.60 | HPGD (0.70) | POLBLMNAKMT2AMEN1RAB9A | |
| SCHEMBL1093663 | 0.59 | KDM4E (0.67) | KMT2AMEN1ALDH1A1MAPTNPSR1 | |
| SCHEMBL25154851 | 0.58 | LMNA (0.63) | POLBLMNAPKMKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109134463-B | β -carboline type 5 phosphodiesterase inhibitor and preparation method and application thereof | 山东大学 | 2020-05-08 | — | — | CN | claimed |
| CN-109134463-B | β -carboline type 5 phosphodiesterase inhibitor and preparation method and application thereof | 山东大学 | 2020-05-08 | — | — | CN | disclosed |