Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 5/20 | 0.54 |
| ▸ | PRKCG | P05129 | 5/20 | 0.54 |
| ▸ | PRKCB | P05771 | 5/20 | 0.54 |
| ▸ | PRKCA | P17252 | 5/20 | 0.54 |
| ▸ | PRKCH | P24723 | 5/20 | 0.54 |
| ▸ | PRKCI | P41743 | 5/20 | 0.54 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.54 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.54 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | PRKACA | P17612 | 3/20 | 0.52 |
| ▸ | PRKACG | P22612 | 3/20 | 0.52 |
| ▸ | PRKACB | P22694 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28591143 | 0.93 | PRKD3 (0.49) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL28394910 | 0.88 | PRKD3 (0.42) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL28602915 | 0.84 | ROCK2 (0.50) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL28399717 | 0.83 | PRKD3 (0.55) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL8828469 | 0.83 | PRKD3 (0.61) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL28910349 | 0.82 | CYP17A1 (0.41) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2199067 | 0.81 | CA1 (0.52) | CYP3A4LMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL8332473 | 0.80 | CA1 (0.50) | CYP3A4LMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL2761905 | 0.80 | CA1 (0.50) | CYP3A4LMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL13677595 | 0.78 | CYP3A4 (0.58) | PRKD3PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110031557-B | Method for detecting 5-isoquinoline methyl sulfonate and 5-isoquinoline ethyl sulfonate in fasudil hydrochloride | 山东省食品药品检验研究院 | 2021-06-29 | — | — | CN | claimed |
| CN-112986409-A | Method for detecting isoquinoline sulfonate genotoxic impurities in fasudil | 南京亿华药业有限公司 | 2021-06-18 | — | — | CN | claimed |
| CN-112684038-A | Method for detecting 5-isoquinoline ethyl sulfonate in fasudil hydrochloride | 河南省科学院高新技术研究中心 | 2021-04-20 | — | — | CN | claimed |
| CN-109374811-B | Method for detecting 5-isoquinoline ethyl sulfonate in fasudil hydrochloride | 昆药集团股份有限公司 | 2020-11-03 | — | — | CN | claimed |
| CN-111624276-A | Method for simultaneously detecting genotoxic impurities 5-isoquinoline methyl sulfonate and 5-isoquinoline ethyl sulfonate in fasudil hydrochloride | 北京阳光诺和药物研究股份有限公司 | 2020-09-04 | — | — | CN | claimed |
| CN-111153856-A | Preparation method of fasudil hydrochloride impurity with genotoxicity | 湖南增达生物科技有限公司 | 2020-05-15 | — | — | CN | claimed |
| CN-112684038-B | Method for detecting 5-isoquinoline ethyl sulfonate in fasudil hydrochloride | 河南省科学院高新技术研究中心 | 2022-03-22 | — | — | CN | disclosed |
| CN-110031557-B | Method for detecting 5-isoquinoline methyl sulfonate and 5-isoquinoline ethyl sulfonate in fasudil hydrochloride | 山东省食品药品检验研究院 | 2021-06-29 | — | — | CN | disclosed |
| CN-110441449-B | Method for detecting related substances in fasudil hydrochloride raw material or injection | 昆药集团股份有限公司 | 2021-06-29 | — | — | CN | disclosed |
| CN-112986409-A | Method for detecting isoquinoline sulfonate genotoxic impurities in fasudil | 南京亿华药业有限公司 | 2021-06-18 | — | — | CN | disclosed |
| CN-112684038-A | Method for detecting 5-isoquinoline ethyl sulfonate in fasudil hydrochloride | 河南省科学院高新技术研究中心 | 2021-04-20 | — | — | CN | disclosed |
| CN-111624276-B | Method for simultaneously detecting genotoxic impurities 5-isoquinoline methyl sulfonate and 5-isoquinoline ethyl sulfonate in fasudil hydrochloride | 北京阳光诺和药物研究股份有限公司 | 2021-04-09 | — | — | CN | disclosed |
| CN-109374811-B | Method for detecting 5-isoquinoline ethyl sulfonate in fasudil hydrochloride | 昆药集团股份有限公司 | 2020-11-03 | — | — | CN | disclosed |
| CN-111624276-A | Method for simultaneously detecting genotoxic impurities 5-isoquinoline methyl sulfonate and 5-isoquinoline ethyl sulfonate in fasudil hydrochloride | 北京阳光诺和药物研究股份有限公司 | 2020-09-04 | — | — | CN | disclosed |
| CN-111153856-A | Preparation method of fasudil hydrochloride impurity with genotoxicity | 湖南增达生物科技有限公司 | 2020-05-15 | — | — | CN | disclosed |