Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 7/20 | 0.58 |
| ▸ | PRKCG | P05129 | 7/20 | 0.58 |
| ▸ | PRKCB | P05771 | 7/20 | 0.58 |
| ▸ | PRKCA | P17252 | 7/20 | 0.58 |
| ▸ | PRKCH | P24723 | 7/20 | 0.58 |
| ▸ | PRKCI | P41743 | 7/20 | 0.58 |
| ▸ | PRKCE | Q02156 | 7/20 | 0.58 |
| ▸ | PRKCQ | Q04759 | 7/20 | 0.58 |
| ▸ | PRKCZ | Q05513 | 7/20 | 0.58 |
| ▸ | PRKCD | Q05655 | 7/20 | 0.58 |
| ▸ | PRKD1 | Q15139 | 7/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | PRKACA | P17612 | 5/20 | 0.56 |
| ▸ | PRKACG | P22612 | 5/20 | 0.56 |
| ▸ | PRKACB | P22694 | 5/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11983469 | 0.86 | TNF (0.46) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL6967362 | 0.85 | CYP3A4 (0.59) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL8828469 | 0.84 | PRKD3 (0.61) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL8771380 | 0.83 | CYP3A4 (0.56) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL29546384 | 0.82 | CYP3A4 (0.56) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL30075444 | 0.82 | CA1 (0.61) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL115053 | 0.82 | CYP3A4 (0.56) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL29696494 | 0.82 | CYP3A4 (0.56) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL1551138 | 0.82 | CA1 (0.61) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL117745 | 0.82 | CYP3A4 (0.56) | CYP3A4PRKD3PRKCGPRKCBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11155559-B2 | Sulfonyl-substituted isoquinolines as inhibitors of RHO kinase and hERG potassium channel activity | CHINA RESOURCES PHARMACEUTICAL HOLDINGS COMPANY LIMITED (CN) | 2021-10-26 | — | — | US | disclosed |
| US-20200207772-A1 | ISOQUINOLINYLSULFONYL DERIVATIVE AND USE THEREOF | CHINA RESOURCES PHARMACEUTICAL HOLDINGS COMPANY LIMITED (CN) | 2020-07-02 | — | — | US | disclosed |
| US-9684238-B2 | Fluorene-type compound, photopolymerization initiator comprising said fluorene-type compound, and photosensitive composition containing said photopolymerization initiator | TOKYO OHKA KOGYO CO., LTD. (JP) | 2017-06-20 | — | — | US | disclosed |
| US-9684238-B2 | Fluorene-type compound, photopolymerization initiator comprising said fluorene-type compound, and photosensitive composition containing said photopolymerization initiator | TOKYO OHKA KOGYO CO., LTD. (JP) | 2017-06-20 | — | — | US | disclosed |
| US-20150259321-A1 | FLUORENE-TYPE COMPOUND, PHOTOPOLYMERIZATION INITIATOR COMPRISING SAID FLUORENE-TYPE COMPOUND, AND PHOTOSENSITIVE COMPOSITION CONTAINING SAID PHOTOPOLYMERIZATION INITIATOR | DAITO CHEMIX CORPORATION (JP) | 2015-09-17 | — | — | US | disclosed |
| US-20150259321-A1 | FLUORENE-TYPE COMPOUND, PHOTOPOLYMERIZATION INITIATOR COMPRISING SAID FLUORENE-TYPE COMPOUND, AND PHOTOSENSITIVE COMPOSITION CONTAINING SAID PHOTOPOLYMERIZATION INITIATOR | DAITO CHEMIX CORPORATION (JP) | 2015-09-17 | — | — | US | disclosed |
| US-20090253705-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME LLC | 2009-10-08 | — | — | US | disclosed |
| US-20090253705-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME LLC | 2009-10-08 | — | — | US | disclosed |
| EP-1284734-B1 | ISOQUINOLINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CUREGENICS LTD (IL) | 2008-05-21 | — | — | EP | disclosed |
| US-7268142-B2 | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline | PFIZER INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253705-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | ADRB3, ADRB1, ADRB2 | CYP3A4 321/4885PRKD3 207/4885PRKCG 395/4885 |
| US-20200207772-A1 | ISOQUINOLINYLSULFONYL DERIVATIVE AND USE THEREOF | RHOT2, ROCK2, CIT | CYP3A4 1658/4885PRKD3 88/4885PRKCG 255/4885 |
| US-20150259321-A1 | FLUORENE-TYPE COMPOUND, PHOTOPOLYMERIZATION INITIATOR COMPRISING SAID FLUORENE-TYPE COMPOUND, AND PHOTOSENSITIVE COMPOSITION CONTAINING SAID PHOTOPOLYMERIZATION INITIATOR | AFF1, AFF2, FTO | CYP3A4 1245/4885PRKD3 4144/4885PRKCG 3635/4885 |
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | MAPK1, MAPK3, MAPK4 | CYP3A4 1880/4885PRKD3 144/4885PRKCG 1552/4885 |
| US-11155559-B2 | Sulfonyl-substituted isoquinolines as inhibitors of RHO kinase and hERG potassium channel activity | KCNQ2, KCNQ1, KCNH3 | CYP3A4 1298/4885PRKD3 382/4885PRKCG 138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.