Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.35 |
| ▸ | MMP1 | P03956 | 2/20 | 0.31 |
| ▸ | FCER2 | P06734 | 2/20 | 0.31 |
| ▸ | MMP9 | P14780 | 2/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17447794 | 1.00 | BTK (0.35) | BTKMMP1FCER2MMP9MMP3 | |
| SCHEMBL17447827 | 1.00 | BTK (0.35) | BTKMMP1FCER2MMP9MMP3 | |
| SCHEMBL28389945 | 0.83 | MTNR1A (0.34) | MMP1FCER2MMP9MMP3 | |
| SCHEMBL17447789 | 0.83 | MTNR1A (0.34) | MMP1FCER2MMP9MMP3 | |
| SCHEMBL17447840 | 0.81 | BTK (0.35) | BTKEGFR | |
| SCHEMBL17447839 | 0.81 | BTK (0.35) | BTKEGFR | |
| SCHEMBL17447941 | 0.79 | BTK (0.38) | BTKEGFR | |
| SCHEMBL17447921 | 0.79 | BTK (0.38) | BTKEGFR | |
| SCHEMBL17447944 | 0.79 | BTK (0.38) | BTKEGFR | |
| SCHEMBL17443454 | 0.78 | BTK (0.38) | BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106687446-B | 5-amino-4-carbamoyl-pyrazole compounds as selective and irreversible kinase inhibitors of T790M/WT-EGFR and uses thereof | 百济神州(北京)生物科技有限公司 | 2020-04-28 | — | — | CN | disclosed |