Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 9/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 2/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.31 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.31 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2728833 | 1.00 | CTSK (0.37) | CTSKNOTUMABL1PIN1MTOR | |
| SCHEMBL2839634 | 1.00 | CTSK (0.37) | CTSKNOTUMABL1PIN1MTOR | |
| SCHEMBL9606738 | 0.90 | CTSK (0.34) | CTSKNOTUMABL1PIN1MTOR | |
| SCHEMBL2840966 | 0.90 | PIN1 (0.36) | CTSKNOTUMABL1PIN1MTOR | |
| SCHEMBL2840973 | 0.89 | PIN1 (0.40) | CTSKNOTUMABL1PIN1MTOR | |
| SCHEMBL2729920 | 0.89 | PIN1 (0.40) | CTSKNOTUMABL1PIN1MTOR | |
| SCHEMBL2844956 | 0.88 | NOTUM (0.37) | CTSKNOTUMABL1PIN1MTOR | |
| SCHEMBL2727999 | 0.88 | NOTUM (0.37) | CTSKNOTUMABL1PIN1MTOR | |
| SCHEMBL2844950 | 0.88 | NOTUM (0.37) | CTSKNOTUMABL1PIN1MTOR | |
| SCHEMBL2845097 | 0.88 | NOTUM (0.37) | CTSKNOTUMABL1PIN1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |