SCHEMBL28397204

SCHEMBL28397204

Clc1cccc(-c2c[nH]c(-c3ccncc3)n2)c1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK13 O15264 1/20 0.44
RAF1 P04049 1/20 0.44
MAPK12 P53778 1/20 0.44
MAPK11 Q15759 1/20 0.44
MAPK14 Q16539 1/20 0.44
IDO1 P14902 2/20 0.42
JAK2 O60674 2/20 0.41
RHEB Q15382 2/20 0.38
NPC1 O15118 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CDC7 O00311 1/20 0.37
DBF4 Q9UBU7 1/20 0.37
P2RX7 Q99572 1/20 0.37
CCNC P24863 1/20 0.36
CDK8 P49336 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3130628 0.88 IDO1 (0.44) MAPK13RAF1MAPK12MAPK11MAPK14
SCHEMBL31305593 0.88 IDO1 (0.44) MAPK13RAF1MAPK12MAPK11MAPK14
SCHEMBL28402546 0.85 NPY5R (0.48) MAPK14IDO1NPC1RAB9ASMN1; SMN2
SCHEMBL28406433 0.83 JAK2 (0.51) MAPK13RAF1MAPK12MAPK11MAPK14
SCHEMBL31305544 0.82 IDO1 (0.39) IDO1CDK8NUDT1CNR1CNR2
SCHEMBL14060494 0.82 IDO1 (0.39) IDO1CDK8NUDT1CNR1CNR2
SCHEMBL28406414 0.81 IDO1 (0.41) IDO1CYP2D6NUDT1CNR1CNR2
SCHEMBL28627684 0.79 P2RX7 (0.42) IDO1NPC1RAB9AP2RX7NUDT1
SCHEMBL29712840 0.79 P2RX7 (0.42) IDO1NPC1RAB9AP2RX7NUDT1
SCHEMBL28402325 0.78 GRM5 (0.52) MAPK14IDO1NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111057043-A Imidazole compound, preparation method and application thereof, organic weldable protective agent containing imidazole compound and surface treatment method 深圳市贝加电子材料有限公司 2020-04-24 CN claimed