Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GPR88 | Q9GZN0 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127763 | 0.95 | MAPT (0.50) | MAPTALDH1A1FFAR1SOAT1MEN1 | |
| SCHEMBL25392616 | 0.95 | MAPT (0.50) | MAPTALDH1A1FFAR1SOAT1MEN1 | |
| SCHEMBL18924829 | 0.88 | MAPT (0.46) | MAPTALDH1A1FFAR1SOAT1MEN1 | |
| SCHEMBL5724509 | 0.88 | ALDH1A1 (0.59) | MAPTALDH1A1FFAR1SOAT1LMNA | |
| SCHEMBL17173532 | 0.86 | MAPT (0.44) | MAPTALDH1A1FFAR1SOAT1MEN1 | |
| SCHEMBL27871158 | 0.86 | MAPT (0.44) | MAPTALDH1A1FFAR1SOAT1MEN1 | |
| SCHEMBL14244980 | 0.86 | SOAT1 (0.50) | MAPTALDH1A1FFAR1SOAT1TSHR | |
| SCHEMBL696918 | 0.86 | MAPT (0.47) | MAPTALDH1A1FFAR1SOAT1TSHR | |
| SCHEMBL5012805 | 0.85 | MAPT (0.43) | MAPTALDH1A1FFAR1LMNACYP3A4 | |
| SCHEMBL23969102 | 0.85 | MAPT (0.43) | MAPTALDH1A1FFAR1SOAT1GPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111039333-A | Perovskite material, method for preparing same, and secondary battery comprising perovskite material | 三星电子株式会社 | 2020-04-21 | — | — | CN | disclosed |