Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ACACB | O00763 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28400900 | 1.00 | GPR119 (0.52) | GPR119MAPTLMNAALDH1A1ACACB | |
| SCHEMBL28397493 | 1.00 | GPR119 (0.52) | GPR119MAPTLMNAALDH1A1ACACB | |
| SCHEMBL28401004 | 0.91 | MAPT (0.56) | GPR119MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL5239182 | 0.86 | GPR119 (0.63) | GPR119MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL23410150 | 0.85 | GPR119 (0.61) | GPR119LMNASMN1; SMN2USP2 | |
| SCHEMBL29246691 | 0.83 | GPR119 (0.44) | GPR119MAPTLMNAALDH1A1 | |
| SCHEMBL15749513 | 0.83 | GPR119 (0.56) | GPR119MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL5272983 | 0.82 | GPR119 (0.55) | GPR119MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL20305696 | 0.81 | MAPT (0.56) | GPR119MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL20305694 | 0.81 | MAPT (0.56) | GPR119MAPTLMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111072675-A | Nitrogen-containing fused tricyclic derivatives and uses thereof | 广东东阳光药业有限公司 | 2020-04-28 | — | — | CN | disclosed |