Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2839802 | 0.88 | ADRB3 (0.38) | ADRB3ADRA2BADRA2CCTSS | |
| SCHEMBL2841176 | 0.88 | ADRB3 (0.39) | ADRB3ADRA2BADRA2CCTSS | |
| SCHEMBL2872297 | 0.88 | ADRB3 (0.40) | ADRB3ADRA2BADRA2CCTSS | |
| SCHEMBL2843231 | 0.87 | ADRB3 (0.39) | ADRB3ADRA2BADRA2CCTSS | |
| SCHEMBL2838324 | 0.87 | ADRB3 (0.38) | ADRB3ADRA2BADRA2CCTSS | |
| SCHEMBL3555403 | 0.86 | ADRB3 (0.38) | ADRB3ADRA2BADRA2CCTSS | |
| SCHEMBL2839761 | 0.83 | ADRB3 (0.43) | ADRB3ADRA2BADRA2CCTSSCYP3A4 | |
| SCHEMBL2839718 | 0.81 | ADRB3 (0.48) | ADRB3ADRA2BADRA2CCTSSCYP3A4 | |
| SCHEMBL2839727 | 0.81 | ADRB3 (0.48) | ADRB3ADRA2BADRA2CCTSSCYP3A4 | |
| SCHEMBL3549460 | 0.81 | CTSB (0.35) | ADRB3ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659245-B2 | Macrocylic inhibitors of hepatitis C virus | TIBOTEC PHARMACEUTICALS LTD (IE) | 2010-02-09 | — | — | US | disclosed |
| EP-1912981-B1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS | TIBOTEC PHARM LTD (IE) | 2010-01-20 | — | — | EP | disclosed |
| US-20090118312-A1 | Macrocylic Inhibitors of Hepatitis C Virus | JANSSEN SCIENCES IRELAND UC (IE) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118312-A1 | Macrocylic Inhibitors of Hepatitis C Virus | CBR1, HAVCR2, AOC1 | ADRB3 944/4885ADRA2B 2037/4885ADRA2C 705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.