Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203230 | 0.94 | CA9 (0.50) | CYP11B1CYP11B2CYP19A1CA9CYP1A2 | |
| SCHEMBL21468447 | 0.91 | CYP11B1 (0.44) | CYP11B1CYP11B2CYP19A1CA9CYP1A2 | |
| SCHEMBL16339494 | 0.86 | CYP11B1 (0.57) | CYP11B1CYP11B2CYP19A1CA9CYP1A2 | |
| SCHEMBL13619932 | 0.85 | SRC (0.46) | CYP11B1CYP11B2CYP19A1L3MBTL1PDE3B | |
| SCHEMBL9597670 | 0.81 | CA9 (0.61) | CYP11B1CYP11B2CYP19A1CA9CYP1A2 | |
| SCHEMBL28406005 | 0.81 | POLB (0.38) | CYP11B1CYP11B2CYP19A1CYP1A2ALDH1A1 | |
| SCHEMBL3309794 | 0.81 | CYP11B1 (0.55) | CYP11B1CYP11B2CYP19A1CA9CYP1A2 | |
| SCHEMBL10572961 | 0.81 | CYP11B1 (0.52) | CYP11B1CYP11B2CYP19A1CA9CYP1A2 | |
| SCHEMBL23674880 | 0.78 | CA9 (0.54) | CA9ALDH1A1PKMPDE3BPDE3A | |
| SCHEMBL16339815 | 0.77 | CYP11B1 (0.49) | CYP11B1CYP11B2CYP19A1CA9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111196817-B | Tricyclic compounds as BRPF1 inhibitors | 四川大学华西医院 | 2021-06-11 | — | — | CN | disclosed |
| CN-111196817-A | Tricyclic compounds as BRPF1 inhibitors | 四川大学华西医院 | 2020-05-26 | — | — | CN | disclosed |