Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 4/20 | 0.41 |
| ▸ | CMA1 | P23946 | 2/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | S100B | P04271 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL578508 | 0.86 | SRC (0.57) | SRCEGFREIF2AK2AHRCMA1 | |
| SCHEMBL28398373 | 0.85 | CYP11B1 (0.52) | S100BPDE3BPDE3AL3MBTL1POLB | |
| SCHEMBL21468447 | 0.83 | CYP11B1 (0.44) | S100BL3MBTL1POLBCYP19A1CYP11B1 | |
| SCHEMBL31335802 | 0.80 | AHR (0.49) | SRCEGFREIF2AK2AHRCMA1 | |
| SCHEMBL2491904 | 0.80 | AHR (0.50) | EIF2AK2AHRCMA1GRIA1CACNG8 | |
| SCHEMBL2203230 | 0.79 | CA9 (0.50) | S100BPDE3BPDE3AL3MBTL1POLB | |
| SCHEMBL2486755 | 0.77 | GRIA1 (0.51) | EIF2AK2AHRCMA1GRIA1CACNG8 | |
| SCHEMBL31040248 | 0.77 | AHR (0.49) | SRCEGFREIF2AK2AHRCMA1 | |
| SCHEMBL5371439 | 0.77 | ACHE (0.46) | SRCEGFREIF2AK2AHRCMA1 | |
| SCHEMBL2060700 | 0.76 | S100B (0.37) | SRCEGFRS100BPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143389-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | WO | disclosed |