SCHEMBL28398570

SCHEMBL28398570

O=C(O)c1nc(F)cnc1O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.37
ASPH Q12797 2/20 0.37
KDM8 Q8N371 2/20 0.37
ALDH1A1 P00352 3/20 0.34
MAPT P10636 2/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
LMNA P02545 1/20 0.32
HSD17B10 Q99714 1/20 0.32
HCAR2 Q8TDS4 2/20 0.31
CYP3A4 P08684 1/20 0.31
ALOX15 P16050 1/20 0.31
TSHR P16473 1/20 0.31
BLM P54132 1/20 0.31
AGER Q15109 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
NAPRT Q6XQN6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27541592 0.83 KDM4E (0.37) KDM4EASPHKDM8ALDH1A1MAPT
Favipiravir SCHEMBL587913 0.82 LCK (0.34) ALDH1A1SMN1; SMN2MEN1KMT2ALMNA
SCHEMBL24025413 0.81 KDM4E (0.38) KDM4EASPHKDM8ALDH1A1MAPT
SCHEMBL29622124 0.80
Favipiravir SCHEMBL21085196 0.80 LCK (0.33) MEN1KMT2ATSHR
Favipiravir SCHEMBL30725561 0.80 LCK (0.33) MEN1KMT2ATSHR
SCHEMBL28945984 0.78 ALDH1A1 (0.37) KDM4EASPHKDM8ALDH1A1MAPT
SCHEMBL24146634 0.77 NPSR1 (0.47) KDM4EALDH1A1SMN1; SMN2HSD17B10NPSR1
SCHEMBL24069013 0.75 ALDH1A1 (0.37) KDM4EALDH1A1MAPTSMN1; SMN2MEN1
SCHEMBL27570827 0.75 ATR (0.42) KDM4EALDH1A1MAPTSMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113252800-A HPLC (high performance liquid chromatography) detection method for Pilarvir and related substances thereof and application of method 北京四环制药有限公司 2021-08-13 CN claimed
CN-113135862-A Synthetic method of 6-fluoro-3-hydroxypyrazine-2-carboxylic acid 宁夏常晟药业有限公司 2021-07-20 CN claimed
CN-117517529-A Method for detecting fapirrevir and related substances thereof by HPLC and application of method 北京四环制药有限公司 2024-02-06 CN disclosed
CN-113252800-B Method for detecting fapirrevir and related substances thereof by HPLC and application of method 北京四环制药有限公司 2024-01-02 CN disclosed
CN-111249229-B Stable fampicin injection and preparation method thereof 北京阜康仁生物制药科技有限公司 2023-05-02 CN disclosed
CN-111214446-B Peruvir L-arginine salt freeze-dried preparation for injection 瑞阳制药股份有限公司 2022-02-25 CN disclosed
CN-114075145-A Favipiravir salt, crystal form and preparation method thereof 广东东阳光药业有限公司 2022-02-22 CN disclosed
CN-111228226-B Freeze-dried preparation of pyrrosia faberi for injection and preparation method thereof 瑞阳制药有限公司 2021-12-28 CN disclosed
CN-113252800-A HPLC (high performance liquid chromatography) detection method for Pilarvir and related substances thereof and application of method 北京四环制药有限公司 2021-08-13 CN disclosed
CN-113135862-A Synthetic method of 6-fluoro-3-hydroxypyrazine-2-carboxylic acid 宁夏常晟药业有限公司 2021-07-20 CN disclosed
CN-113135862-A Synthetic method of 6-fluoro-3-hydroxypyrazine-2-carboxylic acid 宁夏常晟药业有限公司 2021-07-20 CN disclosed
CN-113135862-A Synthetic method of 6-fluoro-3-hydroxypyrazine-2-carboxylic acid 宁夏常晟药业有限公司 2021-07-20 CN disclosed
CN-111249229-A Stable favipiravir injection and preparation method thereof 北京阜康仁生物制药科技有限公司 2020-06-09 CN disclosed
CN-111228226-A Freeze-dried preparation of pyrrosia faberi for injection and preparation method thereof 瑞阳制药有限公司 2020-06-05 CN disclosed
CN-111214446-A Peruvir L-arginine salt freeze-dried preparation for injection 瑞阳制药有限公司 2020-06-02 CN disclosed