Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27271884 | 0.86 | KIF11 (0.49) | KIF11MEN1KMT2ANOTUMNR1H4 | |
| SCHEMBL19461904 | 0.81 | KIF11 (0.44) | KIF11MEN1KMT2ANOTUMNR1H4 | |
| SCHEMBL28381646 | 0.80 | KIF11 (0.43) | KIF11MEN1KMT2A | |
| SCHEMBL28401976 | 0.79 | MEN1 (0.46) | KIF11MEN1KMT2ANR1H4ATM | |
| SCHEMBL3710923 | 0.79 | KIF11 (0.51) | KIF11MEN1KMT2ASCN9APOLB | |
| SCHEMBL3710890 | 0.79 | KIF11 (0.51) | KIF11MEN1KMT2ANOTUMSCN9A | |
| SCHEMBL9444016 | 0.78 | MEN1 (0.52) | KIF11MEN1KMT2ANR1H4ATM | |
| SCHEMBL3714103 | 0.78 | KIF11 (0.50) | KIF11MEN1KMT2ASCN9A | |
| SCHEMBL19461868 | 0.77 | KIF11 (0.41) | KIF11MEN1KMT2ANOTUMNR1H4 | |
| SCHEMBL28402057 | 0.77 | MEN1 (0.43) | KIF11MEN1KMT2ANR1H4ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111196804-B | TGF-beta R1 inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-111196804-A | TGF- β R1 inhibitor and application thereof | 南京圣和药业股份有限公司 | 2020-05-26 | — | — | CN | disclosed |