Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28400285 | 0.79 | KIF11 (0.47) | MEN1KMT2AKIF11NR1H4ATM | |
| SCHEMBL28720409 | 0.79 | MEN1 (0.38) | MEN1KMT2AKIF11NR1H4ATM | |
| SCHEMBL28402057 | 0.78 | MEN1 (0.43) | MEN1KMT2AKIF11NR1H4ATM | |
| SCHEMBL25408607 | 0.78 | KMT2A (0.53) | MEN1KMT2AMAPTPOLBNPC1 | |
| SCHEMBL28402380 | 0.77 | MEN1 (0.42) | MEN1KMT2A | |
| SCHEMBL9444016 | 0.76 | MEN1 (0.52) | MEN1KMT2AKIF11NR1H4ATM | |
| SCHEMBL28242033 | 0.74 | KMT2A (0.53) | MEN1KMT2AKIF11MAPTNPC1 | |
| SCHEMBL28643962 | 0.73 | MEN1 (0.48) | MEN1KMT2AKIF11NR1H4ATM | |
| SCHEMBL440172 | 0.73 | MEN1 (0.52) | MEN1KMT2AKIF11MAPTNPC1 | |
| SCHEMBL20789189 | 0.72 | MEN1 (0.40) | MEN1KMT2AKIF11MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111196804-B | TGF-beta R1 inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-114341145-A | Chemical compound | 博拉公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-111196804-A | TGF- β R1 inhibitor and application thereof | 南京圣和药业股份有限公司 | 2020-05-26 | — | — | CN | disclosed |