Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.63 |
| ▸ | BCR | P11274 | 9/20 | 0.63 |
| ▸ | PRKCA | P17252 | 5/20 | 0.63 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.63 |
| ▸ | KIT | P10721 | 4/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.57 |
| ▸ | EGFR | P00533 | 5/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | PRKACG | P22612 | 1/20 | 0.54 |
| ▸ | PRKACB | P22694 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | PRKCG | P05129 | 1/20 | 0.54 |
| ▸ | PRKCB | P05771 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | PRKCH | P24723 | 1/20 | 0.54 |
| ▸ | PRKCI | P41743 | 1/20 | 0.54 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.54 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29855980 | 1.00 | ABL1 (0.63) | ABL1BCRPRKCAPRKCDKIT | |
| SCHEMBL3004681 | 0.86 | ABL1 (0.75) | ABL1BCRPRKCAPRKCDKIT | |
| SCHEMBL29928272 | 0.86 | ABL1 (0.61) | ABL1BCRPRKCAPRKCDKIT | |
| SCHEMBL29912657 | 0.86 | ABL1 (0.75) | ABL1BCRPRKCAPRKCDKIT | |
| SCHEMBL3009103 | 0.83 | ABL1 (0.67) | ABL1BCRPRKCAPRKCDKIT | |
| SCHEMBL4894119 | 0.83 | ABL1 (0.65) | ABL1BCRPRKCAPRKCDPDGFRB | |
| SCHEMBL29855956 | 0.83 | ABL1 (0.67) | ABL1BCRPRKCAPRKCDKIT | |
| SCHEMBL3004033 | 0.79 | ABL1 (0.72) | ABL1BCRPRKCAPRKCDKIT | |
| SCHEMBL4373707 | 0.79 | ABL1 (0.72) | ABL1BCRPRKCAPRKCDKIT | |
| SCHEMBL12320924 | 0.78 | ABL1 (0.78) | ABL1BCRPRKCAKITPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111072636-A | Synthesis method of flumatinib | 江苏豪森药业集团有限公司 | 2020-04-28 | — | — | CN | claimed |
| CN-111072636-B | Synthesis method of flumatinib | 江苏豪森药业集团有限公司 | 2022-08-23 | — | — | CN | disclosed |
| CN-111072636-A | Synthesis method of flumatinib | 江苏豪森药业集团有限公司 | 2020-04-28 | — | — | CN | disclosed |