SCHEMBL28403180

SCHEMBL28403180

COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(OC(F)F)cc5)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCCC1

nearest known ligand 0.89

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MET P08581 20/20 0.89
KIT P10721 3/20 0.70
KDR P35968 3/20 0.70
FLT3 P36888 3/20 0.70
PDGFRA P16234 2/20 0.70
MST1R Q04912 1/20 0.70
PDGFRB P09619 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28403297 0.99 MET (0.89) METKITKDRFLT3PDGFRA
SCHEMBL28401327 0.96 MET (0.88) METKITKDRFLT3PDGFRA
SCHEMBL28403285 0.95 MET (0.86) METKITKDRFLT3PDGFRA
SCHEMBL28407223 0.94 MET (1.00) METKITKDRFLT3PDGFRA
SCHEMBL28411232 0.94 MET (1.00) METKITKDRFLT3PDGFRA
SCHEMBL28408302 0.93 MET (0.90) METKITKDRFLT3PDGFRA
SCHEMBL28407173 0.92 MET (0.91) METKITKDRFLT3PDGFRA
SCHEMBL28399673 0.91 MET (0.88) METKITKDRFLT3PDGFRA
SCHEMBL28411228 0.91 MET (0.89) METKITKDRFLT3PDGFRA
SCHEMBL28407386 0.91 MET (0.89) METKITKDRFLT3PDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107474039-B 4-phenoxy substituted quinoline compound containing triazazolone and imidazole and application thereof 沈阳药科大学 2020-05-01 CN claimed
CN-107474039-B 4-phenoxy substituted quinoline compound containing triazazolone and imidazole and application thereof 沈阳药科大学 2020-05-01 CN disclosed