Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.56 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.56 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.56 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL28890188 | 0.92 | ALDH1A1 (0.61) | KMT2AALDH1A1PTK2BMEN1KDM4E | |
| SCHEMBL29994009 | 0.92 | KMT2A (0.69) | KMT2AALDH1A1PTK2BMEN1KDM4E | |
| Benzene SCHEMBL28006345 | 0.92 | KMT2A (0.69) | KMT2AALDH1A1PTK2BMEN1KDM4E | |
| SCHEMBL301123 | 0.92 | KMT2A (0.69) | KMT2AALDH1A1PTK2BMEN1KDM4E | |
| Bicarbonate SCHEMBL29943962 | 0.91 | KMT2A (0.67) | KMT2AALDH1A1PTK2BMEN1KDM4E | |
| SCHEMBL3864160 | 0.91 | KMT2A (0.67) | KMT2AALDH1A1PTK2BMEN1KDM4E | |
| Bicarbonate SCHEMBL20694840 | 0.91 | KMT2A (0.67) | KMT2AALDH1A1PTK2BMEN1KDM4E | |
| SCHEMBL1999543 | 0.91 | KMT2A (0.67) | KMT2AALDH1A1PTK2BMEN1KDM4E | |
| SCHEMBL4649029 | 0.91 | KMT2A (0.67) | KMT2AALDH1A1PTK2BMEN1KDM4E | |
| Benzene SCHEMBL28294580 | 0.91 | KMT2A (0.67) | KMT2AALDH1A1PTK2BMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106946701-B | Salicylic acid-based fumarate derivative and application thereof in treating Parkinson's disease and other neurodegenerative diseases | 重庆纽源生物科技有限公司 | 2020-05-15 | — | — | CN | disclosed |