SCHEMBL28403334

SCHEMBL28403334

Clc1ccc(-c2nc(-c3ccncc3)[nH]c2-c2ccccc2)cc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAPK13 O15264 16/20 1.00
MAPK12 P53778 16/20 1.00
MAPK11 Q15759 16/20 1.00
MAPK14 Q16539 16/20 1.00
RAF1 P04049 11/20 1.00
BRAF P15056 5/20 0.81
GCGR P47871 5/20 0.73
MAPK9 P45984 1/20 0.71
BRDT Q58F21 1/20 0.66
ALOX5 P09917 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2649589 0.95 MAPK13 (0.90) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL29355176 0.90 BRAF (1.00) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL7643418 0.90 BRAF (1.00) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL2650500 0.88 MAPK14 (0.79) MAPK13MAPK12MAPK11MAPK14RAF1
Bromide SCHEMBL7648283 0.87 BRAF (0.95) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL2647098 0.87 MAPK14 (0.80) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL28398004 0.87 MAPK13 (0.77) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL7645951 0.85 MAPK13 (0.74) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL7648286 0.85 BRAF (0.91) MAPK13MAPK12MAPK11MAPK14RAF1
SCHEMBL6469559 0.85 MAPK13 (0.78) MAPK13MAPK12MAPK11MAPK14RAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111057043-A Imidazole compound, preparation method and application thereof, organic weldable protective agent containing imidazole compound and surface treatment method 深圳市贝加电子材料有限公司 2020-04-24 CN claimed