Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.91 |
| ▸ | RAF1 | P04049 | 9/20 | 0.91 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.74 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.74 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.74 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.74 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.65 |
| ▸ | GCGR | P47871 | 3/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29355176 | 0.95 | BRAF (1.00) | BRAFRAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL7643418 | 0.95 | BRAF (1.00) | BRAFRAF1MAPK13MAPK12MAPK11 | |
| Bromide SCHEMBL7648283 | 0.93 | BRAF (0.95) | BRAFRAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL12856388 | 0.90 | BRAF (0.90) | BRAFRAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL28403334 | 0.85 | MAPK13 (1.00) | BRAFRAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL2214546 | 0.81 | BRAF (1.00) | BRAFRAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL2649589 | 0.80 | MAPK13 (0.90) | BRAFRAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL15075633 | 0.80 | BRAF (0.91) | BRAFRAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL7645951 | 0.79 | MAPK13 (0.74) | BRAFRAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL20242995 | 0.79 | RAF1 (0.70) | BRAFRAF1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173254-A2 | NOVEL TREATMENT OF NEUROTRAUMATIC CONDITIONS WITH A RAF INHIBITOR | SMITHKLINE BEECHAM PLC (GB) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064422-A2 | NOVEL TREATMENT OF NEUROTRAUMATIC CONDITIONS WITH RAF INHIBITOR | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-11-02 | — | — | WO | disclosed |