Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 13/20 | 0.74 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.74 |
| ▸ | MAPK11 | Q15759 | 13/20 | 0.74 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.74 |
| ▸ | RAF1 | P04049 | 10/20 | 0.74 |
| ▸ | BRAF | P15056 | 3/20 | 0.71 |
| ▸ | GCGR | P47871 | 3/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | TEK | Q02763 | 1/20 | 0.59 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.59 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.58 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28403334 | 0.85 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL15075623 | 0.84 | MAPK13 (0.71) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL6465030 | 0.84 | MAPK13 (0.71) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL7643418 | 0.83 | BRAF (1.00) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL29355176 | 0.83 | BRAF (1.00) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL27934209 | 0.82 | MAPK13 (0.67) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL6469484 | 0.81 | NOX1 (0.88) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| Bromide SCHEMBL7648283 | 0.81 | BRAF (0.95) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL6469341 | 0.80 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL2649589 | 0.80 | MAPK13 (0.90) | MAPK13MAPK12MAPK11MAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173254-A2 | NOVEL TREATMENT OF NEUROTRAUMATIC CONDITIONS WITH A RAF INHIBITOR | SMITHKLINE BEECHAM PLC (GB) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064422-A2 | NOVEL TREATMENT OF NEUROTRAUMATIC CONDITIONS WITH RAF INHIBITOR | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-11-02 | — | — | WO | disclosed |