SCHEMBL28405385

SCHEMBL28405385

COc1ccc(C(C)[SiH](c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA4 P22748 1/20 0.48
ALDH1A1 P00352 4/20 0.47
ACP3 P15309 3/20 0.47
LTA4H P09960 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.42
PBRM1 Q86U86 1/20 0.42
TRPA1 O75762 1/20 0.42
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA7 P43166 1/20 0.42
CA9 Q16790 1/20 0.42
CA14 Q9ULX7 1/20 0.42
PKM P14618 1/20 0.42
KDM1A O60341 1/20 0.42
NPC1 O15118 1/20 0.41
MAPT P10636 1/20 0.41
RAB9A P51151 1/20 0.41
PAX8 Q06710 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28481733 1.00 CA4 (0.48) CA4ALDH1A1ACP3LTA4HL3MBTL1
SCHEMBL28405384 1.00 CA4 (0.48) CA4ALDH1A1ACP3LTA4HL3MBTL1
SCHEMBL28473700 0.84 AKR1C3 (0.54) L3MBTL1MAPTTSHRTDP1
SCHEMBL28473703 0.84 AKR1C3 (0.54) L3MBTL1MAPTTSHRTDP1
SCHEMBL25909657 0.81 TAAR1 (0.41) ALDH1A1TSHR
SCHEMBL25909658 0.81 TAAR1 (0.41) ALDH1A1TSHR
SCHEMBL3175071 0.77 ALDH1A1 (0.44) CA4ALDH1A1ACP3LTA4HL3MBTL1
SCHEMBL30587820 0.76 ACP3 (0.41) CA4ALDH1A1ACP3LTA4HL3MBTL1
SCHEMBL28399569 0.76 ALDH1A1 (0.39) ALDH1A1NPC1MAPTNPSR1MEN1
SCHEMBL28471422 0.76 ALDH1A1 (0.39) ALDH1A1NPC1MAPTNPSR1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111203276-B Application of chiral bidentate phosphite ligand, hydrosilation reaction catalyst and application thereof, and preparation method of chiral silane 郑州大学 2022-11-18 CN disclosed
CN-111690009-B Phosphine pyridine oxazoline compound, metal complex, preparation method and application thereof 中国科学院上海有机化学研究所 2021-11-02 CN disclosed
CN-111690009-A Phosphine pyridine oxazoline compound, metal complex, preparation method and application thereof 中国科学院上海有机化学研究所 2020-09-22 CN disclosed
CN-111203276-A Application of chiral bidentate phosphite ligand, hydrosilation reaction catalyst and application thereof, and preparation method of chiral silane 郑州大学 2020-05-29 CN disclosed