Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNB1 | Q14721 | 3/20 | 0.69 |
| ▸ | KCNB2 | Q92953 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29494543 | 0.90 | KCNB1 (0.55) | KCNB1KCNB2 | |
| SCHEMBL29494278 | 0.87 | KCNB1 (0.52) | KCNB1KCNB2 | |
| SCHEMBL29494539 | 0.82 | MEN1 (0.53) | — | |
| SCHEMBL29793667 | 0.82 | MEN1 (0.53) | — | |
| SCHEMBL28404707 | 0.82 | MEN1 (0.53) | — | |
| SCHEMBL28257405 | 0.82 | KCNB1 (0.70) | KCNB1KCNB2KCNH2 | |
| SCHEMBL29793705 | 0.82 | KCNB1 (1.00) | KCNB1KCNB2KCNH2 | |
| SCHEMBL29494489 | 0.81 | — | — | |
| SCHEMBL29494343 | 0.80 | — | — | |
| SCHEMBL29494533 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-111108092-A | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-05-05 | — | — | CN | disclosed |