Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNB1 | Q14721 | 12/20 | 1.00 |
| ▸ | KCNB2 | Q92953 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.59 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.53 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28402250 | 0.91 | KCNB1 (0.83) | KCNB1KCNB2KCNH2KCNA5KCNK2 | |
| SCHEMBL28413523 | 0.85 | KCNB1 (0.73) | KCNB1KCNB2KCNH2KCNA5KCNK2 | |
| SCHEMBL28413244 | 0.83 | KCNB1 (0.71) | KCNB1KCNB2KCNH2KCNA5KCNK2 | |
| SCHEMBL16583815 | 0.82 | KCNB1 (0.69) | KCNB1KCNB2HPGDLMNAPOLB | |
| SCHEMBL28405947 | 0.82 | KCNB1 (0.69) | KCNB1KCNB2KCNH2 | |
| SCHEMBL28410953 | 0.81 | KCNB1 (0.68) | KCNB1KCNB2KCNH2KCNA5KCNK2 | |
| SCHEMBL28257357 | 0.80 | KCNB1 (0.76) | KCNB1KCNB2KCNH2KCNA5KCNK2 | |
| SCHEMBL29793887 | 0.80 | KCNB1 (0.66) | KCNB1KCNB2ALDH1A1KDM4EHPGD | |
| SCHEMBL28257362 | 0.80 | KCNB1 (0.66) | KCNB1KCNB2ALDH1A1KDM4EHPGD | |
| SCHEMBL28413196 | 0.80 | KCNB1 (0.66) | KCNB1KCNB2KCNH2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |