Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1SLC9A3
The experimentally established mechanism targets of Adenine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.63 |
| ▸ | PI4KA | P42356 | 2/20 | 0.63 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.63 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.63 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.63 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | XDH | P47989 | 1/20 | 0.63 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenine SCHEMBL28406878 | 0.88 | PI4KA (0.71) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL28145520 | 0.86 | PI4KA (0.79) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL28186581 | 0.82 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL31591098 | 0.82 | PI4KA (0.76) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL14125908 | 0.82 | PI4KA (0.76) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL1871839 | 0.81 | PI4KA (0.88) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL28116475 | 0.81 | PI4KA (0.96) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL385842 | 0.79 | LMNA (0.92) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL28404254 | 0.79 | PI4KA (0.92) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL8111 | 0.79 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111254109-A | Method for in vitro fertilization and embryo culture of bovine oocytes and transport culture solution | 天津博裕力牧科技有限公司 | 2020-06-09 | — | — | CN | claimed |
| CN-111254109-A | Method for in vitro fertilization and embryo culture of bovine oocytes and transport culture solution | 天津博裕力牧科技有限公司 | 2020-06-09 | — | — | CN | disclosed |