Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Adenine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.76 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.76 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.76 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.76 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | DRD3 | P35462 | 1/20 | 0.76 |
| ▸ | XDH | P47989 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenine SCHEMBL14125908 | 1.00 | PI4KA (0.76) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL385842 | 0.91 | LMNA (0.92) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL1871839 | 0.89 | PI4KA (0.88) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL28162074 | 0.89 | PI4KA (0.69) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL28186581 | 0.87 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL3416956 | 0.87 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL3413249 | 0.87 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL3414606 | 0.87 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL8111 | 0.87 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL28113157 | 0.87 | PI4KA (0.71) | PI4KAPI4K2BPI4K2API4KBLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120022522-A | Drug-loaded microneedle, drug-loaded microneedle patch and electrically-controlled drug release microneedle system | 成都邦迈医创科技有限公司 | 2025-05-23 | — | — | CN | claimed |
| CN-120022522-A | Drug-loaded microneedle, drug-loaded microneedle patch and electrically-controlled drug release microneedle system | 成都邦迈医创科技有限公司 | 2025-05-23 | — | — | CN | disclosed |