Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 11/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25057908 | 1.00 | KEAP1 (0.45) | KEAP1NFE2L2KDM4EALDH1A1HPGD | |
| SCHEMBL26357069 | 0.91 | KEAP1 (0.42) | KEAP1NFE2L2KDM4EALDH1A1HPGD | |
| SCHEMBL26357056 | 0.91 | KEAP1 (0.48) | KEAP1NFE2L2ALDH1A1KMT2AMEN1 | |
| SCHEMBL24299824 | 0.88 | KEAP1 (0.45) | KEAP1NFE2L2 | |
| SCHEMBL29539657 | 0.88 | KEAP1 (0.45) | KEAP1NFE2L2 | |
| SCHEMBL29539842 | 0.87 | NMT1 (0.42) | KEAP1NFE2L2 | |
| SCHEMBL26357227 | 0.87 | NMT1 (0.42) | KEAP1NFE2L2 | |
| SCHEMBL29540066 | 0.87 | KMT2A (0.39) | KEAP1NFE2L2KDM4EALDH1A1HPGD | |
| SCHEMBL22922526 | 0.87 | KMT2A (0.39) | KEAP1NFE2L2KDM4EALDH1A1HPGD | |
| SCHEMBL29539804 | 0.87 | KMT2A (0.47) | KEAP1NFE2L2KMT2AMEN1CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110256305-B | Naphthalene sulfonamide compound, preparation method and application | 中国药科大学 | 2020-05-26 | — | — | CN | disclosed |