Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 20/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 9/20 | 0.45 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24299824 | 1.00 | KEAP1 (0.45) | KEAP1NFE2L2SQSTM1 | |
| SCHEMBL22922540 | 0.93 | KEAP1 (0.42) | KEAP1NFE2L2SQSTM1 | |
| SCHEMBL26357056 | 0.91 | KEAP1 (0.48) | KEAP1NFE2L2 | |
| SCHEMBL26357227 | 0.89 | NMT1 (0.42) | KEAP1NFE2L2 | |
| SCHEMBL29539842 | 0.89 | NMT1 (0.42) | KEAP1NFE2L2 | |
| SCHEMBL28407007 | 0.88 | KEAP1 (0.45) | KEAP1NFE2L2 | |
| SCHEMBL25057908 | 0.88 | KEAP1 (0.45) | KEAP1NFE2L2 | |
| SCHEMBL26356238 | 0.87 | KEAP1 (0.60) | KEAP1NFE2L2SQSTM1 | |
| SCHEMBL29732411 | 0.86 | KEAP1 (0.41) | KEAP1NFE2L2 | |
| SCHEMBL29539949 | 0.86 | KEAP1 (0.56) | KEAP1NFE2L2SQSTM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3978471-B1 | NAPHTHALENESULFONAMIDE COMPOUND, PREPARATION METHOD, AND APPLICATION | UNIV CHINA PHARMA (CN) | 2023-02-22 | — | — | EP | disclosed |
| EP-3978471-A1 | NAPHTHALENESULFONAMIDE COMPOUND, PREPARATION METHOD, AND APPLICATION | China Pharmaceutical University (CN) | 2022-04-06 | — | — | EP | disclosed |