Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28403230 | 0.83 | KDM4E (0.59) | KMT2AMEN1RAB9AMAPTKDM4E | |
| SCHEMBL28406922 | 0.81 | PKM (0.60) | POLBTDP1SMN1; SMN2TP53KMT2A | |
| SCHEMBL28414530 | 0.78 | MAPT (0.56) | POLBTDP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13253112 | 0.70 | KMT2A (0.81) | POLBTDP1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14208824 | 0.68 | NPC1 (0.69) | POLBSMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL23657914 | 0.68 | TDP1 (0.85) | POLBTDP1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3954215 | 0.68 | MAPT (0.68) | POLBSMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL12287298 | 0.67 | MAPT (0.82) | POLBSMN1; SMN2TP53KMT2AMEN1 | |
| Ammonia Solution, Strong SCHEMBL28437729 | 0.67 | ALDH1A1 (0.76) | POLBSMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL924520 | 0.67 | KMT2A (0.53) | TDP1SMN1; SMN2KMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111253326-B | 2-substituted-4-functionalized N (O, S) -quinazol derivative and application thereof | 河北美信医药科技有限公司 | 2020-12-08 | — | — | CN | disclosed |
| CN-111253326-A | 2-substituted-4-functionalized N (O, S) -quinazol derivative and application thereof | 河北美信医药科技有限公司 | 2020-06-09 | — | — | CN | disclosed |