Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.52 |
| ▸ | FBP1 | P09467 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | TEK | Q02763 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28409421 | 0.84 | EGFR (0.61) | EGFRERBB2 | |
| SCHEMBL28409241 | 0.83 | EPHA2 (0.49) | EGFRKDREPHB4EPHA2 | |
| SCHEMBL28181389 | 0.82 | EGFR (0.56) | EGFRKDREPHB4FBP1AURKA | |
| SCHEMBL28696327 | 0.78 | EPHA2 (0.67) | EGFRKDREPHB4FBP1ERBB2 | |
| SCHEMBL28403915 | 0.77 | EGFR (0.74) | EGFRKDREPHB4FBP1AURKA | |
| SCHEMBL12609963 | 0.75 | — | — | |
| SCHEMBL12609961 | 0.75 | — | — | |
| SCHEMBL28403896 | 0.75 | EGFR (0.59) | EGFRERBB2 | |
| SCHEMBL28412441 | 0.75 | EGFR (0.58) | EGFRKDREPHB4FBP1AURKA | |
| SCHEMBL27822000 | 0.74 | FBP1 (0.53) | EGFRKDREPHB4FBP1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107200715-B | Quinazoline derivative and application thereof in preparation of antitumor drugs | 陕西师范大学 | 2020-05-29 | — | — | CN | disclosed |