Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 9/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28407491 | 0.83 | EGFR (0.57) | EPHA2EGFRKDREPHB4 | |
| SCHEMBL28181381 | 0.78 | EGFR (0.53) | EGFRKDREPHB4 | |
| SCHEMBL28181389 | 0.78 | EGFR (0.56) | EPHA2EGFRKDREPHB4 | |
| SCHEMBL28407194 | 0.77 | EGFR (0.42) | EGFR | |
| SCHEMBL28407547 | 0.77 | EGFR (0.49) | EPHA2EGFR | |
| SCHEMBL28409415 | 0.76 | EGFR (0.44) | EPHA2EGFRKDR | |
| SCHEMBL28182145 | 0.75 | EGFR (0.51) | EPHA2EGFRKDREPHB4 | |
| SCHEMBL28409421 | 0.73 | EGFR (0.61) | EGFR | |
| SCHEMBL28409239 | 0.73 | EGFR (0.63) | EPHA2EGFRKDREPHB4 | |
| SCHEMBL4890627 | 0.72 | EPHA2 (0.71) | EPHA2EGFRKDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107200715-B | Quinazoline derivative and application thereof in preparation of antitumor drugs | 陕西师范大学 | 2020-05-29 | — | — | CN | disclosed |