SCHEMBL28409934

SCHEMBL28409934

CCc1ccc(C(=O)c2ccccc2C(=O)c2ccccc2)c(CC)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 2/20 0.49
ALDH1A1 P00352 3/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
LTC4S Q16873 1/20 0.45
TP53 P04637 1/20 0.44
CDC25A P30304 1/20 0.44
CDC25B P30305 1/20 0.44
HSD17B10 Q99714 1/20 0.44
PTGS2 P35354 2/20 0.43
MAPT P10636 2/20 0.43
MAPK1 P28482 1/20 0.43
POLB P06746 1/20 0.43
PPARG P37231 1/20 0.43
PPARD Q03181 1/20 0.43
PPARA Q07869 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11233529 0.95 TP53 (0.47) AKR1C3ALDH1A1CYP1A2CYP2C19LTC4S
SCHEMBL8864717 0.89 SMN1; SMN2 (0.50) AKR1C3ALDH1A1L3MBTL1CYP3A4CYP2C9
SCHEMBL5310985 0.84 AKR1C3 (0.56) AKR1C3ALDH1A1L3MBTL1CYP1A2CYP3A4
SCHEMBL22389564 0.82 PTGS2 (0.55) AKR1C3ALDH1A1TP53PTGS2PPARG
SCHEMBL9856867 0.81 SRD5A2 (0.51) AKR1C3ALDH1A1L3MBTL1MAPTMEN1
SCHEMBL4604200 0.81 MEN1 (0.62) ALDH1A1L3MBTL1CYP1A2CYP3A4CYP2C19
SCHEMBL11231215 0.81 SRD5A2 (0.59) AKR1C3ALDH1A1CYP2C9LTC4STP53
SCHEMBL27476186 0.81 KDM4E (0.62) AKR1C3ALDH1A1LTC4STP53CDC25A
SCHEMBL10350347 0.80 PTGS2 (0.54) ALDH1A1L3MBTL1TP53PTGS2PTGS1
SCHEMBL723171 0.79 AKR1C3 (0.57) AKR1C3ALDH1A1L3MBTL1PTGS2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111278879-A Curable compositions based on immiscible reactive components and block copolymers 阿科玛法国公司 2020-06-12 CN disclosed