Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | KCNB1 | Q14721 | 3/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | KDM6B | O15054 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28405957 | 0.88 | TDP1 (0.51) | HPGDSMN1; SMN2NPSR1RXFP1L3MBTL1 | |
| SCHEMBL28402845 | 0.81 | KCNB1 (0.60) | TSHRHSD17B10KMT2ACREBBPKCNB1 | |
| SCHEMBL10943849 | 0.78 | TDP1 (0.67) | HPGDSMN1; SMN2TSHRHSD17B10KMT2A | |
| SCHEMBL24413627 | 0.75 | TSHR (0.53) | SMN1; SMN2TSHRHSD17B10KMT2ALMNA | |
| SCHEMBL24107347 | 0.75 | MCL1 (0.50) | HPGDTSHRHSD17B10KMT2AMEN1 | |
| SCHEMBL2771810 | 0.74 | CFD (0.61) | HPGDL3MBTL1TSHRHSD17B10KMT2A | |
| SCHEMBL28405128 | 0.73 | TAS1R3 (0.56) | HPGDSMN1; SMN2NPSR1RXFP1L3MBTL1 | |
| SCHEMBL24073948 | 0.73 | TDP1 (0.46) | TSHRHSD17B10KMT2AFABP4MEN1 | |
| SCHEMBL7902296 | 0.72 | TSHR (0.57) | TSHRHSD17B10KMT2ALMNA | |
| SCHEMBL3388835 | 0.72 | TSHR (0.62) | HPGDSMN1; SMN2NPSR1RXFP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-111108092-A | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-05-05 | — | — | CN | disclosed |