Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNB1 | Q14721 | 16/20 | 0.73 |
| ▸ | KCNB2 | Q92953 | 1/20 | 0.73 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.53 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29793705 | 0.85 | KCNB1 (1.00) | KCNB1KCNB2KCNA5KCNH2KCNK2 | |
| SCHEMBL28402250 | 0.83 | KCNB1 (0.83) | KCNB1KCNB2KCNA5KCNH2KCNK2 | |
| SCHEMBL28410651 | 0.83 | KCNB1 (0.78) | KCNB1KCNA5KCNH2KCNK2 | |
| SCHEMBL28257417 | 0.83 | KCNB1 (0.48) | KCNB1KCNB2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL28406389 | 0.82 | KCNB1 (0.72) | KCNB1KCNB2KCNA5KCNH2CYP3A4 | |
| SCHEMBL28406386 | 0.80 | ALDH1A1 (0.49) | KCNB1KCNB2MEN1CYP1A2CYP3A4 | |
| SCHEMBL28410953 | 0.79 | KCNB1 (0.68) | KCNB1KCNB2KCNA5KCNH2KCNK2 | |
| SCHEMBL28257357 | 0.77 | KCNB1 (0.76) | KCNB1KCNB2KCNA5KCNH2KCNK2 | |
| SCHEMBL29793564 | 0.76 | KCNB1 (0.75) | KCNB1KCNB2KCNA5KCNH2KCNK2 | |
| SCHEMBL28408023 | 0.76 | KCNB1 (0.75) | KCNB1KCNB2KCNA5KCNH2KCNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-111108092-A | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-05-05 | — | — | CN | disclosed |