Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.31 |
| ▸ | MPI | P34949 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4327246 | 0.81 | ALDH1A1 (0.37) | KDM4EGRM5OGANFE2L2MPI | |
| SCHEMBL18012141 | 0.81 | OGA (0.34) | KDM4EGRM5OGAFGFR1FGFR2 | |
| SCHEMBL20897967 | 0.79 | ASIC3 (0.37) | KDM4EGRM5OGAMPIL3MBTL1 | |
| SCHEMBL19602251 | 0.79 | TLR8 (0.35) | GRM5OGAFGFR1FGFR2FGFR4 | |
| SCHEMBL17035461 | 0.75 | GRM5 (0.34) | KDM4EGRM5OGANFE2L2MPI | |
| SCHEMBL22031519 | 0.75 | GRM5 (0.34) | KDM4EGRM5OGANFE2L2MPI | |
| SCHEMBL29994316 | 0.75 | GRM5 (0.34) | KDM4EGRM5OGANFE2L2MPI | |
| SCHEMBL18827520 | 0.75 | GRM5 (0.34) | KDM4EGRM5OGANFE2L2MPI | |
| SCHEMBL22031506 | 0.74 | NAPRT (0.35) | — | |
| SCHEMBL31098142 | 0.74 | NAPRT (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285873-B | RET inhibitor, pharmaceutical composition thereof and application thereof | 广东东阳光药业股份有限公司 | 2024-10-15 | — | — | CN | disclosed |
| CN-111285874-B | RET inhibitor, pharmaceutical composition thereof and application thereof | 广东东阳光药业股份有限公司 | 2024-08-09 | — | — | CN | disclosed |
| CN-111285874-A | RET inhibitors, pharmaceutical compositions thereof and uses thereof | 广东东阳光药业有限公司 | 2020-06-16 | — | — | CN | disclosed |
| CN-111285873-A | RET inhibitors, pharmaceutical compositions thereof and uses thereof | 广东东阳光药业有限公司 | 2020-06-16 | — | — | CN | disclosed |