Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.83 |
| ▸ | PDE2A | O00408 | 1/20 | 0.80 |
| ▸ | PDE9A | O76083 | 1/20 | 0.80 |
| ▸ | PDE4A | P27815 | 1/20 | 0.80 |
| ▸ | PDE6C | P51160 | 1/20 | 0.80 |
| ▸ | PDE1A | P54750 | 1/20 | 0.80 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.80 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25013455 | 0.91 | PDE5A (0.91) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL28417274 | 0.87 | PDE5A (0.65) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL7094034 | 0.87 | KDM4E (0.83) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL6628860 | 0.86 | KMT2A (0.85) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL22273422 | 0.86 | POLB (0.78) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL16854873 | 0.86 | POLB (0.80) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL1071 | 0.86 | KMT2A (0.83) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL29655374 | 0.86 | KMT2A (0.83) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL21995693 | 0.86 | KMT2A (0.83) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL7000746 | 0.85 | KDM4E (0.80) | PDE5AKDM4EPDE2APDE9APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111297868-A | Use of a composition comprising a heterocyclic compound for the manufacture of a medicament for the treatment of phosphodiesterase mediated diseases | 黄泳华 | 2020-06-19 | — | — | CN | claimed |
| CN-111297868-A | Use of a composition comprising a heterocyclic compound for the manufacture of a medicament for the treatment of phosphodiesterase mediated diseases | 黄泳华 | 2020-06-19 | — | — | CN | disclosed |