Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2840117 | 0.92 | TP53 (0.48) | ALDH1A1GLATP53LMNAOPRM1 | |
| SCHEMBL2838360 | 0.91 | TP53 (0.47) | ALDH1A1GLATP53LMNAOPRM1 | |
| SCHEMBL2840994 | 0.90 | TP53 (0.58) | ALDH1A1TP53LMNA | |
| SCHEMBL2837650 | 0.89 | TP53 (0.57) | TP53LMNAOPRM1OPRD1 | |
| SCHEMBL2841104 | 0.88 | TP53 (0.47) | TP53LMNAOPRM1OPRD1L3MBTL1 | |
| SCHEMBL13381728 | 0.86 | CHRM3 (0.46) | ALDH1A1GLALMNACHRM3 | |
| SCHEMBL2841776 | 0.84 | LMNA (0.52) | ALDH1A1TP53LMNAL3MBTL1 | |
| SCHEMBL2847041 | 0.82 | TP53 (0.55) | TP53LMNAOPRM1OPRD1 | |
| SCHEMBL2836208 | 0.81 | LMNA (0.53) | TP53LMNA | |
| SCHEMBL2838161 | 0.81 | MAPT (0.61) | TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | claimed |
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |