Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2837650 | 0.94 | TP53 (0.57) | LMNATP53 | |
| SCHEMBL2843070 | 0.91 | L3MBTL1 (0.47) | LMNAALDH1A1SMN1; SMN2GAAHTT | |
| SCHEMBL2847041 | 0.88 | TP53 (0.55) | LMNATP53 | |
| SCHEMBL2847484 | 0.87 | L3MBTL1 (0.59) | ALDH1A1GAAL3MBTL1TSHR | |
| SCHEMBL13381640 | 0.87 | TSHR (0.47) | ALDH1A1L3MBTL1TSHR | |
| SCHEMBL2838161 | 0.86 | MAPT (0.61) | LMNATP53TSHR | |
| SCHEMBL2836208 | 0.86 | LMNA (0.53) | LMNATP53 | |
| SCHEMBL2840994 | 0.86 | TP53 (0.58) | LMNAALDH1A1TP53 | |
| SCHEMBL2840117 | 0.86 | TP53 (0.48) | LMNAALDH1A1TP53L3MBTL1 | |
| SCHEMBL2843660 | 0.86 | L3MBTL1 (0.52) | ALDH1A1GAAL3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | claimed |
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |