Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 19/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29788602 | 1.00 | MAPT (0.64) | MAPTPKMALDH1A1MEN1KMT2A | |
| SCHEMBL18036523 | 0.82 | MAPT (0.75) | MAPTPKMALDH1A1MEN1KMT2A | |
| SCHEMBL443596 | 0.81 | HPGD (0.73) | MAPTPKMALDH1A1MEN1KMT2A | |
| SCHEMBL29788558 | 0.81 | HPGD (0.73) | MAPTPKMALDH1A1MEN1KMT2A | |
| SCHEMBL15340797 | 0.79 | MAPT (0.66) | MAPTPKMALDH1A1MEN1KMT2A | |
| SCHEMBL1911905 | 0.78 | MAPT (1.00) | MAPTPKMALDH1A1MEN1KMT2A | |
| SCHEMBL5058321 | 0.78 | MAPT (0.69) | MAPTPKMALDH1A1MEN1KMT2A | |
| SCHEMBL375310 | 0.78 | ALDH1A1 (0.67) | MAPTPKMALDH1A1MEN1KMT2A | |
| SCHEMBL22652006 | 0.78 | MAPT (0.69) | MAPTPKMALDH1A1MEN1KMT2A | |
| SCHEMBL31129978 | 0.78 | ALDH1A1 (0.67) | MAPTPKMALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111217816-B | FLT3 kinase inhibitor and preparation and application thereof | 中国科学院上海药物研究所 | 2022-08-16 | — | — | CN | disclosed |
| CN-111217816-A | FLT3 kinase inhibitor and preparation and application thereof | 中国科学院上海药物研究所 | 2020-06-02 | — | — | CN | disclosed |