Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635719 | 0.85 | ALDH1A1 (0.53) | TSHRALDH1A1MAPTHSD17B10MAOB | |
| SCHEMBL6982655 | 0.83 | KDM4E (0.45) | TSHRALDH1A1MAPTHSD17B10MEN1 | |
| SCHEMBL1436063 | 0.82 | ALDH1A1 (0.51) | TSHRALDH1A1MAPTHSD17B10MAOB | |
| SCHEMBL6977127 | 0.82 | ALDH1A1 (0.51) | TSHRALDH1A1MAPTHSD17B10MAOB | |
| SCHEMBL21132539 | 0.81 | ALDH1A1 (0.50) | TSHRALDH1A1MAPTHSD17B10MAOB | |
| SCHEMBL11400583 | 0.80 | TSHR (0.53) | TSHRALDH1A1MAPTHSD17B10MAOB | |
| SCHEMBL1757222 | 0.78 | ALDH1A1 (0.60) | TSHRALDH1A1MAPTHSD17B10PKM | |
| SCHEMBL17223287 | 0.76 | TSHR (0.55) | TSHRALDH1A1MAPTHSD17B10MAOB | |
| SCHEMBL158238 | 0.76 | TSHR (0.55) | TSHRALDH1A1MAPTHSD17B10MAOB | |
| SCHEMBL28415213 | 0.75 | L3MBTL1 (0.50) | ALDH1A1HSD17B10TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112457326-B | Aromatic heterocyclic lactam compound, preparation method and application | 上海凌达生物医药有限公司 | 2022-02-15 | — | — | CN | disclosed |
| CN-110950876-B | Furanolactam compounds, preparation method and application | 上海凌达生物医药有限公司 | 2021-08-17 | — | — | CN | disclosed |
| CN-112457326-A | Aromatic heterocyclic lactam compound, preparation method and application | 上海凌达生物医药有限公司 | 2021-03-09 | — | — | CN | disclosed |
| CN-110950876-A | Furanolactam compounds, preparation method and application | 如东凌达生物医药科技有限公司 | 2020-04-03 | — | — | CN | disclosed |