SCHEMBL28426985

SCHEMBL28426985

O=C(O)c1ccc([N+](=O)[O-])cc1CCl

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.58
TDP1 Q9NUW8 2/20 0.58
CYP3A4 P08684 1/20 0.58
ALOX15 P16050 1/20 0.58
MAPT P10636 3/20 0.50
TP53 P04637 2/20 0.50
HTT P42858 1/20 0.50
KMT2A Q03164 4/20 0.49
MEN1 O00255 2/20 0.48
PLA2G1B P04054 1/20 0.48
ATG4B Q9Y4P1 1/20 0.48
CYP1A2 P05177 1/20 0.47
GAA P10253 1/20 0.47
CTSV O60911 1/20 0.47
CTSL P07711 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.46
MAOA P21397 1/20 0.46
MAOB P27338 1/20 0.46
TSHR P16473 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27273977 0.88 KMT2A (0.50) ALDH1A1TDP1CYP3A4ALOX15MAPT
SCHEMBL9427061 0.88 KMT2A (0.50) ALDH1A1TDP1CYP3A4ALOX15MAPT
SCHEMBL6304897 0.87 ALDH1A1 (0.55) ALDH1A1TDP1CYP3A4ALOX15MAPT
SCHEMBL6304900 0.87 ALDH1A1 (0.55) ALDH1A1TDP1CYP3A4ALOX15MAPT
SCHEMBL6393059 0.87 ALDH1A1 (0.54) ALDH1A1TDP1CYP3A4ALOX15MAPT
SCHEMBL28068351 0.86 ALDH1A1 (0.62) ALDH1A1TDP1CYP3A4ALOX15MAPT
SCHEMBL6398092 0.85 ALDH1A1 (0.53) ALDH1A1TDP1CYP3A4ALOX15MAPT
SCHEMBL10584268 0.85 KMT2A (0.64) ALDH1A1TDP1CYP3A4ALOX15MAPT
SCHEMBL28428327 0.85 ALDH1A1 (0.60) ALDH1A1TDP1CYP3A4ALOX15MAPT
SCHEMBL2557500 0.85 ALDH1A1 (0.60) ALDH1A1TDP1CYP3A4ALOX15MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111440194-A Amoxicillin derivative and preparation method and application thereof 华南农业大学 2020-07-24 CN disclosed