Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 5/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHKA | P35790 | 1/20 | 0.42 |
| ▸ | POLQ | O75417 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28857426 | 0.83 | CHRNB2 (0.54) | LMNATSHRKMT2AKDM4EALDH1A1 | |
| SCHEMBL361412 | 0.83 | POLB (0.43) | LMNAKMT2AKDM4ECDC7DBF4 | |
| SCHEMBL442790 | 0.81 | CHRNB2 (0.59) | LMNATSHRKMT2AALDH1A1HPGD | |
| Benzene SCHEMBL1720409 | 0.81 | CHRNB2 (0.59) | LMNATSHRKMT2AALDH1A1HPGD | |
| SCHEMBL9136344 | 0.81 | LMNA (0.62) | LMNATSHRKMT2AALDH1A1CHRNB2 | |
| SCHEMBL28512951 | 0.80 | POLQ (0.41) | LMNATSHRKMT2AKDM4ECDC7 | |
| SCHEMBL27921411 | 0.80 | NOTUM (0.58) | LMNATSHRKMT2AKDM4EALDH1A1 | |
| SCHEMBL14192258 | 0.79 | KMT2A (0.49) | KMT2AKDM4ECHRM5CHKAPOLQ | |
| SCHEMBL9357885 | 0.79 | CHRNB2 (0.61) | LMNATSHRKMT2AALDH1A1CHRNB2 | |
| SCHEMBL11444462 | 0.79 | LMNA (0.59) | LMNATSHRALDH1A1CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114829447-A | Brush prodrug and use thereof | 麻省理工学院 | 2022-07-29 | — | — | CN | disclosed |
| CN-111263758-A | Branched multifunctional macromers and related polymers and uses thereof | 麻省理工学院 | 2020-06-09 | — | — | CN | disclosed |