SCHEMBL28428682

SCHEMBL28428682

Oc1c(O)c2ccc(Br)nc2c2nc(Br)ccc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.32
MAPT P10636 2/20 0.32
BRD4 O60885 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TDP1 Q9NUW8 2/20 0.31
TP53 P04637 2/20 0.31
HTT P42858 2/20 0.31
MEN1 O00255 1/20 0.31
USP2 O75604 1/20 0.31
HSP90AA1 P07900 1/20 0.31
KMT2A Q03164 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
TSHR P16473 2/20 0.31
CYP3A4 P08684 1/20 0.31
NPC1 O15118 1/20 0.31
MITF O75030 1/20 0.31
LMNA P02545 1/20 0.31
GAA P10253 1/20 0.31
AGTR1 P30556 1/20 0.31
RAB9A P51151 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14884180 0.74 CCR1 (0.33) KDM4EMAPTTDP1TP53HTT
SCHEMBL15761471 0.72 NQO2 (0.39) MAPTALDH1A1TDP1HTTMEN1
SCHEMBL29266809 0.71 ACHE (0.62) KDM4EMAPTALDH1A1MEN1HSP90AA1
SCHEMBL30618508 0.71 ACHE (0.62) KDM4EMAPTALDH1A1MEN1HSP90AA1
SCHEMBL29001877 0.70 KDM4E (0.38) KDM4EMAPTALDH1A1MEN1KMT2A
SCHEMBL30379766 0.70 KDM4E (0.38) KDM4EMAPTALDH1A1MEN1KMT2A
SCHEMBL57528 0.69 CCR1 (0.43) KDM4EMAPTTDP1TP53HTT
SCHEMBL16827263 0.69 MAPT (0.34) KDM4EMAPTALDH1A1TDP1TP53
SCHEMBL24508237 0.68 CCR1 (0.34) RAB9A
SCHEMBL31493925 0.67 CCR1 (0.42) KDM4EMAPTTDP1TP53HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111057056-B Organic-aqueous phase heavy metal chelating agent and preparation method thereof 南京艾姆材料科技有限公司 2021-03-16 CN claimed
CN-111057056-A Organic-aqueous phase efficient heavy metal chelating agent and preparation method thereof 南京艾姆材料科技有限公司 2020-04-24 CN claimed
CN-111057056-B Organic-aqueous phase heavy metal chelating agent and preparation method thereof 南京艾姆材料科技有限公司 2021-03-16 CN disclosed
CN-111057056-A Organic-aqueous phase efficient heavy metal chelating agent and preparation method thereof 南京艾姆材料科技有限公司 2020-04-24 CN disclosed