Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.62 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.48 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.48 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15764692 | 0.85 | XDH (0.59) | XDHPFKFB2PFKFB1PFKFB3 | |
| SCHEMBL29940648 | 0.85 | XDH (0.60) | XDHLRRK2PFKFB2PFKFB1PFKFB3 | |
| SCHEMBL28427144 | 0.85 | XDH (0.62) | XDHLRRK2PFKFB2PFKFB1PFKFB3 | |
| SCHEMBL29940720 | 0.85 | XDH (0.62) | XDHLRRK2PFKFB2PFKFB1PFKFB3 | |
| SCHEMBL28430806 | 0.85 | XDH (0.60) | XDHLRRK2PFKFB2PFKFB1PFKFB3 | |
| SCHEMBL28432415 | 0.79 | POLB (0.53) | LRRK2GAA | |
| SCHEMBL22803955 | 0.77 | STING1 (0.57) | XDHPFKFB2PFKFB1PFKFB3 | |
| SCHEMBL28587237 | 0.77 | XDH (1.00) | XDH | |
| SCHEMBL28429325 | 0.76 | POLB (0.58) | GAA | |
| SCHEMBL28435041 | 0.74 | NPC1 (0.74) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111072634-A | 1-substituted-3-substituted-5-substituted amide-1H-indole compound and preparation method and application thereof | 中国医科大学 | 2020-04-28 | — | — | CN | claimed |
| CN-111072634-B | 1-substituted-3-substituted-5-substituted amide-1H-indole compound and preparation method and application thereof | 中国医科大学 | 2022-07-22 | — | — | CN | disclosed |
| CN-111072634-A | 1-substituted-3-substituted-5-substituted amide-1H-indole compound and preparation method and application thereof | 中国医科大学 | 2020-04-28 | — | — | CN | disclosed |