Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.48 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.48 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR1F | P30939 | 1/20 | 0.45 |
| ▸ | STK17B | O94768 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28429317 | 0.85 | XDH (0.62) | XDHPFKFB2PFKFB1PFKFB3 | |
| SCHEMBL29940648 | 0.78 | XDH (0.60) | XDHPFKFB2PFKFB1PFKFB3IMPDH2 | |
| SCHEMBL29940720 | 0.78 | XDH (0.62) | XDHPFKFB2PFKFB1PFKFB3 | |
| SCHEMBL28430806 | 0.78 | XDH (0.60) | XDHPFKFB2PFKFB1PFKFB3IMPDH2 | |
| SCHEMBL28427144 | 0.78 | XDH (0.62) | XDHPFKFB2PFKFB1PFKFB3 | |
| SCHEMBL6599646 | 0.75 | IMPDH2 (0.56) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL22803955 | 0.75 | STING1 (0.57) | XDHMAPTRAB9APFKFB2PFKFB1 | |
| SCHEMBL28587237 | 0.74 | XDH (1.00) | XDH | |
| SCHEMBL6599204 | 0.74 | GPR84 (0.55) | XDHNPC1RAB9APFKFB2PFKFB1 | |
| SCHEMBL18343649 | 0.73 | XDH (0.54) | XDHPFKFB2PFKFB1PFKFB3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951316-B2 | Enhancers of induced pluripotent stem cell reprogramming | CITY OF HOPE (US) | 2018-04-24 | — | — | US | disclosed |
| US-20150191701-A1 | ENHANCERS OF INDUCED PLURIPOTENT STEM CELL REPROGRAMMING | CITY OF HOPE | 2015-07-09 | — | — | US | disclosed |
| US-8962322-B2 | Enhancers of induced pluripotent stem cell reprogramming | CITY OF HOPE | 2015-02-24 | — | — | US | disclosed |
| US-20140154805-A1 | ENHANCERS OF INDUCED PLURIPOTENT STEM CELL REPROGRAMMING | CITY OF HOPE (US) | 2014-06-05 | — | — | US | disclosed |