SCHEMBL28429392

SCHEMBL28429392

O=C(O)CNC(=O)c1cc(B(O)O)cc(C(F)(F)F)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 1/20 0.47
RHOC P08134 4/20 0.46
RHOA P61586 4/20 0.46
EGLN1 Q9GZT9 2/20 0.43
HTT P42858 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
USP5 P45974 1/20 0.40
KDM4E B2RXH2 1/20 0.40
MAPT P10636 1/20 0.40
HIF1A Q16665 1/20 0.40
SLC22A6 Q4U2R8 1/20 0.40
SLC22A8 Q8TCC7 1/20 0.40
GPR139 Q6DWJ6 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
GAA P10253 1/20 0.39
ALDH1A1 P00352 1/20 0.39
POLB P06746 1/20 0.39
CES2 O00748 1/20 0.39
MGLL Q99685 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22400307 0.95 TACR1 (0.43) TACR1RHOCRHOAEGLN1HTT
SCHEMBL22400302 0.95 TACR1 (0.46) TACR1RHOCRHOAEGLN1HTT
SCHEMBL22527595 0.90 TACR1 (0.40) TACR1RHOCRHOAEGLN1HTT
SCHEMBL615919 0.86 TACR1 (0.59) TACR1RHOCRHOAEGLN1HTT
SCHEMBL26334411 0.84 LMNA (0.39) TACR1RHOCRHOAEGLN1USP5
SCHEMBL29125352 0.81 KDM4E (0.42) EGLN1USP5KDM4EMAPTHIF1A
SCHEMBL615458 0.81 TACR1 (0.50) TACR1RHOCRHOAEGLN1HTT
SCHEMBL31148307 0.81 KDM4E (0.42) EGLN1USP5KDM4EMAPTHIF1A
SCHEMBL25677209 0.80 ALDH1A1 (0.42) TACR1RHOCRHOAGAAALDH1A1
SCHEMBL3898783 0.79 KDM4E (0.53) TACR1RHOCRHOAEGLN1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117624207-A Glucose-sensitive albumin binding derivatives 诺和诺德股份有限公司 2024-03-01 CN claimed
CN-111315751-A Glucose-sensitive albumin binding derivatives 诺沃挪第克公司 2020-06-19 CN claimed
CN-117624207-A Glucose-sensitive albumin binding derivatives 诺和诺德股份有限公司 2024-03-01 CN disclosed
CN-111315751-B Glucose-sensitive albumin binding derivatives 诺和诺德股份有限公司 2023-12-12 CN disclosed
CN-111315751-A Glucose-sensitive albumin binding derivatives 诺沃挪第克公司 2020-06-19 CN disclosed