SCHEMBL28429407

SCHEMBL28429407

COc1ccc(NNS(=O)(=O)c2ccc(C)cc2)cc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.77
KDM4E B2RXH2 2/20 0.77
CYP1A2 P05177 2/20 0.77
CYP3A4 P08684 2/20 0.77
CYP2D6 P10635 2/20 0.77
CYP2C9 P11712 2/20 0.77
HPGD P15428 2/20 0.77
ALOX12 P18054 2/20 0.77
CYP2C19 P33261 2/20 0.77
TDP1 Q9NUW8 2/20 0.77
PKM P14618 2/20 0.77
MAPT P10636 1/20 0.77
APOBEC3G Q9HC16 1/20 0.77
IDO1 P14902 4/20 0.75
GAA P10253 4/20 0.66
GFER P55789 1/20 0.66
SMN1; SMN2 Q16637 1/20 0.55
LMNA P02545 1/20 0.54
MAPK1 P28482 1/20 0.54
MEN1 O00255 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9412335 0.88 ALDH1A1 (0.66) ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6
SCHEMBL20817457 0.88 KDM4E (1.00) ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6
SCHEMBL7564170 0.83 GAA (0.76) ALDH1A1KDM4EHPGDTDP1PKM
SCHEMBL30434229 0.83 GAA (0.76) ALDH1A1KDM4EHPGDTDP1PKM
SCHEMBL806437 0.83 GAA (0.76) ALDH1A1KDM4EHPGDTDP1PKM
SCHEMBL16358438 0.82 KDM4E (0.69) ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6
SCHEMBL2788247 0.80 CA1 (0.70) ALDH1A1PKMIDO1GAAGFER
SCHEMBL28403615 0.80 ALDH1A1 (0.83) ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6
SCHEMBL28403159 0.80 CYP1A2 (0.83) ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6
SCHEMBL11161395 0.80 ALDH1A1 (1.00) ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108276305-B Mild method for preparing Sudan red I structural analogue 江西理工大学 2020-07-31 CN claimed
CN-108276305-B Mild method for preparing Sudan red I structural analogue 江西理工大学 2020-07-31 CN disclosed