Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piroctone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 18/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piroctone SCHEMBL4728215 | 1.00 | KDM4E (0.44) | KDM4ELMNATP53CYP1A2ALOX12 | |
| Piroctone SCHEMBL2137231 | 1.00 | KDM4E (0.44) | KDM4ELMNATP53CYP1A2ALOX12 | |
| Piroctone SCHEMBL457354 | 0.99 | KDM4E (0.43) | KDM4ELMNATP53CYP1A2ALOX12 | |
| Piroctone SCHEMBL20598939 | 0.94 | KDM4E (0.40) | KDM4ELMNATP53CYP1A2ALOX12 | |
| Piroctone SCHEMBL30969893 | 0.92 | IDH1 (0.48) | IDH1 | |
| Piroctone SCHEMBL3588 | 0.92 | IDH1 (0.50) | IDH1 | |
| Piroctone SCHEMBL7568492 | 0.92 | IDH1 (0.50) | IDH1 | |
| Piroctone SCHEMBL28331516 | 0.91 | IDH1 (0.47) | IDH1 | |
| Piroctone SCHEMBL10357073 | 0.91 | IDH1 (0.49) | IDH1 | |
| Piroctone SCHEMBL1289257 | 0.91 | IDH1 (0.49) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 22648 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075322-A | Antibacterial mite-killing shampoo and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075375-A | Liquid crystal composition and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| EP-4149415-B1 | SHAMPOO COMPOSITION COMPRISING ALKYL GLUCOSIDE | PROCTER & GAMBLE (US) | 2026-05-20 | — | — | EP | claimed |
| EP-4743053-A1 | ANTIMICROBIAL SYNERGIES | Symrise AG (DE) | 2026-05-20 | — | — | EP | claimed |
| CN-122031332-A | Shampoo containing extract of Yunnan white beads and preparation method thereof | 保山市药品检验检测研究院 | 2026-05-15 | — | — | CN | claimed |
| CN-122031350-A | Long-acting anti-dandruff shampoo based on microbial balance regulation and control and preparation method thereof | 植安星(西安)生物科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| US-20260132356-A1 | MILD WASH COMPOSITION WITH BIODEGRADABLE THICKENER AND ENHANCED MICROBIOTA IMPACT | CONOPCO, INC., D/B/A UNILEVER (US) | 2026-05-14 | — | — | US | claimed |
| CN-121421914-B | Yeast/rice fermentation product filtrate-containing composition with oil control and hair quality maintenance effects | 瑶品养发(桂林)文化有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4429629-B1 | HAIR COMPOSITION COMPRISING A CATIONIC CELLULOSE AND A SILICONE COMPOUND | UNILEVER IP HOLDINGS B V (NL) | 2026-05-06 | — | — | EP | claimed |
| EP-4734945-A1 | WASH COMPOSITION WITH ANIONIC SULFATE AND SULTAINE NOT RELIANT ON PALM KERNEL OIL | Unilever IP Holdings B.V. (NL) | 2026-05-06 | — | — | EP | claimed |
| US-5132107-A | Antidandruff shampoo | LANGE BOUKE J (NL) | 1992-07-21 | — | — | US | claimed |
| EP-0273952-B1 | A TWO PHASE CLEANSING, CONDITIONING AND MEDICINAL TREATMENT SHAMPOO | LANGE, Bouke Jan (NL) | 1992-05-20 | — | — | EP | claimed |
| US-5104645-A | 1-hydroxy-2-pyridinethione metal salt inplatelet form of specific size; a synergizer; effective | THE PROCTOR & GAMBLE COMPANY (US) | 1992-04-14 | — | — | US | claimed |
| WO-1991017237-A1 | CLEANSING PRODUCTS | THE PROCTER & GAMBLE COMPANY (US) | 1991-11-14 | — | — | WO | claimed |
| CN-1055109-A | Cleaning product | PROCTER & GAMBLE (US) | 1991-10-09 | — | — | CN | claimed |
| CN-1053743-A | ANTIDANDRUFF SHAMPOO COMPOSITIONS | PROCTER & GAMBLE (US) | 1991-08-14 | — | — | CN | claimed |
| EP-0347199-A2 | Shampoo composition | UNILEVER PLC (GB) | 1989-12-20 | — | — | EP | claimed |
| EP-0273952-A1 | A TWO PHASE CLEANSING, CONDITIONING AND MEDICINAL TREATMENT SHAMPOO. | LANGE BOUKE JAN | 1988-07-13 | — | — | EP | claimed |
| WO-1988000041-A1 | A TWO PHASE CLEANSING, CONDITIONING AND MEDICINAL TREATMENT SHAMPOO | LANGE BOUKE JAN (NL) | 1988-01-14 | — | — | WO | claimed |
| US-4552754-A | Hair cosmetic composition | LION CORPORATION (JP) | 1985-11-12 | — | — | US | claimed |