Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piroctone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 18/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piroctone SCHEMBL2137231 | 0.99 | KDM4E (0.44) | KDM4ELMNATP53CYP1A2ALOX12 | |
| Piroctone SCHEMBL2843 | 0.99 | KDM4E (0.44) | KDM4ELMNATP53CYP1A2ALOX12 | |
| Piroctone SCHEMBL4728215 | 0.99 | KDM4E (0.44) | KDM4ELMNATP53CYP1A2ALOX12 | |
| Piroctone SCHEMBL20598939 | 0.93 | KDM4E (0.40) | KDM4ELMNATP53CYP1A2ALOX12 | |
| Piroctone SCHEMBL30969893 | 0.91 | IDH1 (0.48) | IDH1 | |
| Piroctone SCHEMBL3588 | 0.91 | IDH1 (0.50) | IDH1 | |
| Piroctone SCHEMBL7568492 | 0.91 | IDH1 (0.50) | IDH1 | |
| Piroctone SCHEMBL28331516 | 0.90 | IDH1 (0.47) | IDH1 | |
| Piroctone SCHEMBL10357073 | 0.90 | IDH1 (0.49) | IDH1 | |
| Piroctone SCHEMBL1289257 | 0.90 | IDH1 (0.49) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9186314-B2 | Compositions and methods for sealing the surface of keratinous substrates | L'OREAL (FR) | 2015-11-17 | — | — | US | disclosed |
| CN-101332163-B | Cosmetic hair compositions containing metal-oxide layered pigments and functionalized metal-oxide layered pigments and methods of use | OREAL | 2015-01-21 | — | — | CN | disclosed |
| US-8658140-B2 | Compositions and methods for treating keratinous substrates | L'OREAL (FR) | 2014-02-25 | — | — | US | disclosed |
| US-8637489-B2 | Clear carrier compositions for lipophilic compounds, and method of treating keratinous substrates using such compositions | L'OREAL (FR) | 2014-01-28 | — | — | US | disclosed |
| US-8632612-B2 | Compositions for dyeing keratin fibers | SEGETIS, INC. (US) | 2014-01-21 | — | — | US | disclosed |
| US-8597668-B2 | Clear carrier compositions for lipophilic compounds, and method of treating keratinous substrates using such compositions | L'OREAL (FR) | 2013-12-03 | — | — | US | disclosed |
| EP-2613760-A2 | COMPOSITIONS FOR DYEING KERATIN FIBERS | Segetis, Inc. (US) | 2013-07-17 | — | — | EP | disclosed |
| US-20130156716-A1 | COMPOSITIONS FOR DYEING KERATIN FIBERS | SEGETIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130149274-A1 | COMPOSITIONS AND METHODS FOR SEALING THE SURFACE OF KERATINOUS SUBSTRATES | L'OREAL S.A. (FR) | 2013-06-13 | — | — | US | disclosed |
| WO-2012033813-A2 | COMPOSITIONS FOR DYEING KERATIN FIBERS | SEGETIS, INC. (US) | 2012-03-15 | — | — | WO | disclosed |
| US-20090074683-A1 | COMPOSITIONS AND METHODS FOR TREATING KERATINOUS SUBSTRATES | L'OREAL (FR) | 2009-03-19 | — | — | US | disclosed |
| US-20090074700-A1 | COMPOSITIONS AND METHODS FOR IMPARTING SHINE ONTO HAIR | L'OREAL (FR) | 2009-03-19 | — | — | US | disclosed |
| US-20090070945-A1 | METHOD OF COLORING HAIR | L'OREAL (FR) | 2009-03-19 | — | — | US | disclosed |
| US-20090071493-A1 | COMPOSITIONS AND METHODS FOR CONDITIONING HAIR | L'OREAL (FR) | 2009-03-19 | — | — | US | disclosed |
| WO-2009036061-A1 | COMPOSITIONS AND METHODS FOR TREATING KERATINOUS SUBSTRATES | L'OREAL (FR) | 2009-03-19 | — | — | WO | disclosed |
| US-20090071495-A1 | COMPOSITIONS AND METHOD FOR SHAPING AND STYLING HAIR | L'OREAL (FR) | 2009-03-19 | — | — | US | disclosed |
| CN-101332163-A | Cosmetic hair compositions containing metal-oxide layered pigments and functionalized metal-oxide layered pigments and methods of use | OREAL (FR) | 2008-12-31 | — | — | CN | disclosed |
| US-20080299059-A1 | COSMETIC COMPOSITIONS CONTAINING FUNCTIONALIZED METAL-OXIDE LAYERED PIGMENTS AND METHODS OF USE | L'OREAL USA PRODUCTS, INC. (FR) | 2008-12-04 | — | — | US | disclosed |
| US-20080299154-A1 | COSMETIC HAIR COMPOSITIONS CONTAINING METAL-OXIDE LAYERED PIGMENTS AND METHODS OF USE | L'OREAL USA PRODUCTS, INC. (US) | 2008-12-04 | — | — | US | disclosed |
| EP-1997472-A1 | Cosmetic hair compositions containing metal-oxide layered pigments and functionalized metal-oxide layered pigments and methods of use | L'Oreal (FR) | 2008-12-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130156716-A1 | COMPOSITIONS FOR DYEING KERATIN FIBERS | KRT18, KRTCAP2, JUP | KDM4E 1148/4885LMNA 230/4885TP53 795/4885 |
| US-20130149274-A1 | COMPOSITIONS AND METHODS FOR SEALING THE SURFACE OF KERATINOUS SUBSTRATES | KRT18, PLOD3, DDC | KDM4E 127/4885LMNA 703/4885TP53 1317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.